GPCs vs. TPCs
Yes, GPCs (general purpose computers) aren't going away. Yes geeks will fight it, but the iPad (and hopefully competitor's devices like it) and appliance computing will be the future for a great, great number of people.
I think the weirdest transition will be from GPC to TPC: "Truly Personal Computing" where each person has their own touch device and borrowing someone's will soon be like asking to borrow someone's toothbrush. (From what I understand, iPad owning 25-50-somethings have to fight their kids/spouse/etc. to keep them from stealing it, mornings, evenings and weekends.)